Meiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast

ABSTRACT: Production of healthy gametes in meiosis relies on the quality control and proper distribution of both nuclear and cytoplasmic contents. Meiotic differentiation naturally eliminates age-induced cellular damage by an unknown mechanism. Using time-lapse fluorescence microscopy in budding yeast, we found that nuclear senescence factors - including protein aggregates, extrachromosomal ribosomal DNA circles, and abnormal nucleolar material - are sequestered away from chromosomes during meiosis II and subsequently eliminated. A similar sequestration and elimination process occurs for the core subunits of the nuclear pore complex in both young and aged cells. Nuclear envelope remodeling drives the formation of a membranous compartment containing the sequestered material. Importantly, de novo gene

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Elçin Ünal 

PROVIDER: S-BIAD15 | bioimages |

REPOSITORIES: bioimages