Image data accompanying the paper "Mitochondrial DNA removal is essential for sperm development and activity"

ABSTRACT: Active mtDNA elimination during spermatogenesis has emerged as a conserved mechanism ensuring the uniparental mitochondrial inheritance in animals. However, given the existence of post-fertilization processes degrading sperm mitochondria, the physiological significance of sperm mtDNA removal is not clear. Here we show that mtDNA clearance is indispensable for sperm development and activity. We uncover a novel mitochondrial exonuclease, Poldip2, that is specially expressed in late spermatogenesis and required for sperm mtDNA elimination in Drosophila. Loss of Poldip2 impairs mtDNA clearance in elongated spermatids and impedes the progression of individualization complexes that strip away cytoplasmic materials and organelles. Over time, poldip2 mutant sperm exhibit marked nuclear genome frag

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PROVIDER: S-BIAD1506 | bioimages |

REPOSITORIES: bioimages