Simulation and quantitative analysis of spatial centromere distribution patterns
Ontology highlight
ABSTRACT: A prominent feature of eukaryotic chromosomes are centromeres, which are specialized regions
of repetitive DNA required for faithful chromosome segregation during cell division. In interphase
cells centromeres are non-randomly positioned in the three-dimensional space of the nucleus in a
cell-type specific manner. The functional relevance and the cellular mechanisms underlying this
observation are unknown, and quantitative methods to measure distribution patterns of
centromeres in 3D space are needed. Here we have developed an analytical framework that
combines robust clustering metrics and advanced modeling techniques for the quantitative analysis
of centromere distributions at the single cell level. To identify a robust quantitative measure for
centromere clustering, we benchmarked six m
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PROVIDER: S-BIAD1602 | bioimages |
REPOSITORIES: bioimages
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