Systems Properties and Spatiotemporal Regulation of Cell Position Variability during Embryogenesis

ABSTRACT: An intriguing question in developmental biology is how do developmental processes achieve high reproducibility among individuals. An in-depth analysis of information contained in phenotypic variability provides an important perspective to address this question. In this work, we present a quantitative and functional analysis of cell position variability during Caenorhabditis elegans embryogenesis. We find that cell position variability is highly deterministic and regulated by intrinsic and extrinsic mechanisms. Positional variability is determined by cell lineage identity and is coupled to diverse developmental properties of cells, including embryonic localization, cell contact, and left-right symmetry. Temporal dynamics of cell position variability are highly concordant, and fate specifica

SUBMITTER: Zhiguang Zhao 

PROVIDER: S-BIAD169 | bioimages | 2019

REPOSITORIES: bioimages