High-throughput 3D engineered paediatric tumour models for precision medicine

ABSTRACT: Precision medicine for paediatric and adult cancers that incorporates drug sensitivity profiling can identify effective therapies for individual patients. However, obtaining adequate biopsy samples for high-throughput (HTP) screening remains challenging, as tumours need to be expanded in culture or patient-derived xenografts – this is time-consuming and often unsuccessful. Herein, we have developed paediatric patient-derived tumour models using an engineered extracellular matrix (ECM) tissue mimic hydrogel system and HTP 3D bioprinting. Gene expression analysis from a neuroblastoma and sarcoma paediatric patient cohort identified key components of the ECM in these tumour types. Engineered hydrogels with ECM-mimic peptides were used to bioprint and create patient-specific tumouroids using p

SUBMITTER: MoonSun Jung 

PROVIDER: S-BIAD2130 | bioimages |

REPOSITORIES: bioimages