Spatial lung niches shape Pseudomonas aeruginosa persistence

ABSTRACT: Chronic Pseudomonas aeruginosa lung infection is a major cause of morbidity and mortality in people with lung disease. Once established, infection is rarely eradicated and often persists despite prolonged antimicrobial therapy, but the mechanisms that support persistence in the human lung remain poorly understood. To define how P. aeruginosa occupies and adapts to diseased lung tissue, we applied host–pathogen spatial transcriptomics to explanted and resected lungs from people with Cystic Fibrosis (CF) and chronic obstructive pulmonary disease (COPD), mapping bacterial niches and transcriptional states in situ.

SUBMITTER: Duy T. Pham 

PROVIDER: S-BIAD3618 | bioimages |

REPOSITORIES: bioimages