Membrane fluidity causes resistance to 5- fluorouracil (5-FU) in DLD1 colon cancer cells.

ABSTRACT: Background/Aim: Resistance to chemotherapy is a major obstacle for patients with unresectable colorectal cancer (CRC); however, the factors that induce chemoresistance have not been elucidated. Lipid composition influences neoplastic behaviour. Therefore, this study examined whether lipid composition affects sensitivity to chemotherapeutic agents in CRC. Materials and Methods: We performed a lipidomic analysis of a CRC xenograft-derived spheroid model to identify potential relationships between the lipid profile and chemoresistance to 5-fluorouracil (5-FU). Genetic and pharmacological modulation of lipid synthesis were also used in the HCT-116 and DLD-1 CRC cell lines to further characterize resistance to 5-FU. Results: Our lipidomic profiling revealed that phospholipids with saturated fat

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BIAD469 | bioimages |

REPOSITORIES: bioimages