The immune-stromal interplay of the cycling, pregnant and aged female reproductive tract (Histology)

ABSTRACT: We investigated whether the magnitude of the female reproductive tract (FRT) organ-wise cyclic inflammatory and remodeling responses naturally occurring during the estrus cycle of young mice lead to a memory of past environmental stimuli and chronic inflammation and fibrosis development in old age. Additionally, we investigated how inflammatory and remodeling responses change in pregnancy. We used single-cell RNA-sequencing (scRNA-seq) to profile how the female reproductive tract is remodeled during the estrus cycle, decidualization, and ageing (Arrayexpress, accession number E-MTAB-11491). Additionally, to explore in vivo spatial transcriptional landscapes, we used the 10x Visium system to profile 27 sections of young ovaries in diestrus, 33 sections of acyclic old ovaries, 27 sections of

ORGANISM(S): Mus musculus (mouse)

SUBMITTER:  

PROVIDER: S-BIAD482 | bioimages |

REPOSITORIES: bioimages