Quantitative, Spatially Defined Expression of Leukocyte Associated Immunoglobulin-like Receptor (LAIR-1) in Non-Small Cell Lung Cancer

ABSTRACT: Targeting the interaction of Leukocyte Associated Immunoglobulin-like Receptor-1 (LAIR-1) and its ligands has been shown to reinstate anti-tumor immunity. In addition, the introduction of the LAIR-1 decoy protein, LAIR-2, sensitizes previously resistant lung tumors to programmed death-1 (PD-1) blockade, indicating the potential of LAIR-1 as an alternative marker for anti-PD-1 resistance in lung cancer. Here, we assessed LAIR-1 as compared to programmed death-ligand 1 (PD-L1) expression in various tumors, with a focus on lung cancer and its histological subtypes using multiplexed quantitative immunofluorescence (mQIF) in 287 (discovery cohort) and 144 (validation cohort) lung cancer patients. Additionally, using multispectral imaging technology on mQIF images, we evaluated the localization

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BIAD513 | bioimages |

REPOSITORIES: bioimages