Human U2OS cells - compound cell-painting experiment (OME-NGFF)

ABSTRACT: "OME-NGFF converted study from idr0016. Phenotypic profiling attempts to summarize multiparametric, feature-based analysis of cellular phenotypes of each sample so that similarities between profiles reflect similarities between samples. This image set provides a basis for testing image-based profiling methods wrt. to their ability to distinguish the effects of small molecules. The images are of U2OS cells treated with each of over 30,000 known bioactive compounds and labeled with six labels that characterize seven organelles (the cell-painting assay). Gustafsdottir et al. (doi:10.1371/journal.pone.0080999) have developed a multiplex cytological profiling assay that "paints the cell" with as many fluorescent markers as possible without compromising our ability to extract rich, quantitative

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PROVIDER: S-BIAD851 | bioimages |

REPOSITORIES: bioimages