Proteomic analysis of CRISPR Cas 9 mediated mdig deletion in triple negative breast cancer cells

ABSTRACT: Background Breast cancer is the leading cause of cancer related deaths in women. Triple negative breast cancers are highly aggressive, have an overall poor prognosis and has limited therapeutic options. Previously, we have identified an environmental induced gene mdig that predicted the overall survival in breast cancer patients and regulated breast cancer cell growth, motility and invasion partially through DNA and histone methylation. Mdig’s role in breast cancer growth and motility has been revealed however a comprehensive analysis of the proteomic profile of mdig affected cells in triple negative breast cancer has not been attempted yet. Methods We applied mass spectrometry technology featuring global proteomics and post translational modifications in triple negative breast cancer ce

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Carruthers 

PROVIDER: S-BSST333 | bioimages |

REPOSITORIES: bioimages