Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics

ABSTRACT: Background The COVID-19 agent, SARS-CoV-2, is conspecific with the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused SARS in 2002. Whereas both viruses share a completely homologous repertoire of proteins and use the same cellular entry receptor, their transmission efficiencies and pathogenetic traits differ. Here, we studied differences in dsRNA abundance and IRF-3 nuclear translocation in SARS and SARS-CoV-2 infected Calu-3 cells under untreated conditions or after treatment with Ruxolitinib, a JAK-STAT-inhibitor, and Camostat Mesylate.

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Simon Schroeder 

PROVIDER: S-BSST525 | bioimages |

SECONDARY ACCESSION(S): 2697049

REPOSITORIES: bioimages