Multi-organ functions of yolk sac during human early development

ABSTRACT: The yolk sac (YS) represents an evolutionarily-conserved extra-embryonic structure that ensures timely delivery of nutritional support and oxygen to the developing embryo. However, the YS remains ill-defined in humans. We therefore assemble a complete single cell 3D map of human YS from 3-8 post conception weeks by integrating multiomic protein and gene expression data. We reveal the YS as a site of primitive and definitive haematopoiesis including a YS-specific accelerated route to macrophage production, a source of nutritional/metabolic support and a regulator of oxygen-carrying capacity. We reconstruct the emergence of primitive haematopoietic stem and progenitor cells from YS hemogenic endothelium and their decline upon stromal support modulation as intraembryonic organs specialise to

ORGANISM(S): Homo sapiens (human)

SUBMITTER:  

PROVIDER: S-DHCA0 | bioimages |

REPOSITORIES: bioimages