Glucose uptake in brown fat cells is dependent on mTOR complex 2–promoted GLUT1 translocation

ABSTRACT:
Brown adipose tissue is the primary site for thermogenesis and can consume, in addition to free fatty acids, a very high amount of glucose from the blood, which can both acutely and chronically affect glucose homeostasis. Here, we show that mechanistic target of rapamycin (mTOR) complex 2 has a novel role in β
3
-adrenoceptor–stimulated glucose uptake in brown adipose tissue. We show that β
3
-adrenoceptors stimulate glucose uptake in brown adipose tissue via a signaling pathway that is comprised of two different parts: one part dependent on cAMP-mediated increases in GLUT1 transcription and de novo synthesis of GLUT1 and another part dependent on mTOR complex 2–s

SUBMITTER: Jessica M. Olsen 

PROVIDER: S-JCBD-201403080 | bioimages |

REPOSITORIES: bioimages