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Gardner1998 - Cell Cycle Goldbeter


ABSTRACT: Gardner1998 - Cell Cycle Goldbeter Mathematical modeling of cell division cycle (CDC) dynamics. The SBML file has been generated by MathSBML 2.6.0.p960929 (Prerelease Version of 29-Sept-2006) 1-October-2006 15:36:36.076517. This model is described in the article: A theory for controlling cell cycle dynamics using a reversibly binding inhibitor. Gardner TS, Dolnik M, Collins JJ. Proc. Natl. Acad. Sci. U.S.A. 1998 Nov; 95(24): 14190-14195 Abstract: We demonstrate, by using mathematical modeling of cell division cycle (CDC) dynamics, a potential mechanism for precisely controlling the frequency of cell division and regulating the size of a dividing cell. Control of the cell cycle is achieved by artificially expressing a protein that reversibly binds and inactivates any one of the CDC proteins. In the simplest case, such as the checkpoint-free situation encountered in early amphibian embryos, the frequency of CDC oscillations can be increased or decreased by regulating the rate of synthesis, the binding rate, or the equilibrium constant of the binding protein. In a more complex model of cell division, where size-control checkpoints are included, we show that the same reversible binding reaction can alter the mean cell mass in a continuously dividing cell. Because this control scheme is general and requires only the expression of a single protein, it provides a practical means for tuning the characteristics of the cell cycle in vivo. This model is hosted on BioModels Database and identified by: BIOMD0000000008. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Nicolas Le Novère  

PROVIDER: BIOMD0000000008 | BioModels | 2005-01-30

REPOSITORIES: BioModels

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A theory for controlling cell cycle dynamics using a reversibly binding inhibitor.

Gardner T S TS   Dolnik M M   Collins J J JJ  

Proceedings of the National Academy of Sciences of the United States of America 19981101 24


We demonstrate, by using mathematical modeling of cell division cycle (CDC) dynamics, a potential mechanism for precisely controlling the frequency of cell division and regulating the size of a dividing cell. Control of the cell cycle is achieved by artificially expressing a protein that reversibly binds and inactivates any one of the CDC proteins. In the simplest case, such as the checkpoint-free situation encountered in early amphibian embryos, the frequency of CDC oscillations can be increase  ...[more]

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