Dataset Information
Markevich2004_MAPK_AllRandomElementary
Ontology highlight
ABSTRACT:
SUBMITTER: 
Nicolas Le Novère
PROVIDER: BIOMD0000000030 | BioModels | 2005-05-26
REPOSITORIES: BioModels
Publications
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades.
The Journal of cell biology 20040126 3
Mitogen-activated protein kinase (MAPK) cascades can operate as bistable switches residing in either of two different stable states. MAPK cascades are often embedded in positive feedback loops, which are considered to be a prerequisite for bistable behavior. Here we demonstrate that in the absence of any imposed feedback regulation, bistability and hysteresis can arise solely from a distributive kinetic mechanism of the two-site MAPK phosphorylation and dephosphorylation. Importantly, the report ...[more]