Models,Multiomics

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Ferreira2003_CML_generation2

ABSTRACT: The model should reproduce the figure 2F of the article. The equation 7 has been split into equations 7a-7c, in order to take into account the different flux rates of Lysine and CML formation from Schiff. The model was tested in Jarnac (SBML L2 V1) and Copasi (SBML L2 V3). To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

DISEASE(S): Amyloidosis,Diabetes Mellitus

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000053 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:
Action DRS
BIOMD0000000053?filename=BIOMD0000000053-biopax2.owl Owl
BIOMD0000000053?filename=BIOMD0000000053-biopax3.owl Owl
BIOMD0000000053?filename=BIOMD0000000053-matlab.m Other
BIOMD0000000053?filename=BIOMD0000000053-octave.m Other
BIOMD0000000053?filename=BIOMD0000000053.m Other
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Publications

A quantitative model of the generation of N(epsilon)-(carboxymethyl)lysine in the Maillard reaction between collagen and glucose.

Ferreira António E N AE   Ponces Freire Ana M J AM   Voit Eberhard O EO  

The Biochemical journal 20031101 Pt 1

The Maillard reaction between reducing sugars and amino groups of biomolecules generates complex structures known as AGEs (advanced glycation endproducts). These have been linked to protein modifications found during aging, diabetes and various amyloidoses. To investigate the contribution of alternative routes to the formation of AGEs, we developed a mathematical model that describes the generation of CML [ N(epsilon)-(carboxymethyl)lysine] in the Maillard reaction between glucose and collagen.  ...[more]

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