Models

Dataset Information

0

Leloup2003_CircClock_LD


ABSTRACT: This model is described in the paper Toward a detailed computational model for the mammalian circadian clock . In this model only interlocked negative and positive regulation of Per, Cry, Bmal gene are involved. Some initial values were not provided, therefore they were chosen to fit the curves from the paper. Figure2C is re-produced by odeSolver. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Enuo He  

PROVIDER: BIOMD0000000078 | BioModels | 2006-10-17

REPOSITORIES: BioModels

altmetric image

Publications

Toward a detailed computational model for the mammalian circadian clock.

Leloup Jean-Christophe JC   Goldbeter Albert A  

Proceedings of the National Academy of Sciences of the United States of America 20030529 12


We present a computational model for the mammalian circadian clock based on the intertwined positive and negative regulatory loops involving the Per, Cry, Bmal1, Clock, and Rev-Erb alpha genes. In agreement with experimental observations, the model can give rise to sustained circadian oscillations in continuous darkness, characterized by an antiphase relationship between Per/Cry/Rev-Erbalpha and Bmal1 mRNAs. Sustained oscillations correspond to the rhythms autonomously generated by suprachiasmat  ...[more]

Similar Datasets

2006-10-17 | BIOMD0000000073 | BioModels
2006-10-19 | BIOMD0000000074 | BioModels
2024-02-21 | GSE246853 | GEO
2010-03-31 | GSE14909 | GEO
2010-06-05 | E-GEOD-14909 | biostudies-arrayexpress
| PRJNA344857 | ENA
2007-11-07 | E-GEOD-454 | biostudies-arrayexpress
2021-11-19 | PXD019499 | Pride
2011-09-30 | E-GEOD-31958 | biostudies-arrayexpress
2020-01-24 | PXD000425 | Pride