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Fuentes2005_ZymogenActivation

ABSTRACT: . . . SBML level 2 code generated for the JWS Online project by Jacky Snoep using PySCeS Run this model online at http://jjj.biochem.sun.ac.za To cite JWS Online please refer to: Olivier, B.G. and Snoep, J.L. (2004) Web-based modelling using JWS Online , Bioinformatics, 20:2143-2144 . . . . . . The model reproduces Fig 1A of the paper. The model was successfully tested on MathSBML. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2006 The BioModels Team. For more information see the terms of use .

SUBMITTER: Nicolas Le Novère  

PROVIDER: BIOMD0000000092 | BioModels | 2007-03-05

REPOSITORIES: BioModels

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Kinetics of intra- and intermolecular zymogen activation with formation of an enzyme-zymogen complex.

Fuentes Matilde Esther ME   Varón Ramón R   García-Moreno Manuela M   Valero Edelmira E  

The FEBS journal 20050101 1

A mathematical description was made of an autocatalytic zymogen activation mechanism involving both intra- and intermolecular routes. The reversible formation of an active intermediary enzyme-zymogen complex was included in the intermolecular activation route, thus allowing a Michaelis-Menten constant to be defined for the activation of the zymogen towards the active enzyme. Time-concentration equations describing the evolution of the species involved in the system were obtained. In addition, we  ...[more]

PMID: 15634334

Publication: 1/2

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