Legewie2006_apoptosis_WT
Ontology highlight
ABSTRACT:
SUBMITTER: 
Nicolas Le Novère
PROVIDER: BIOMD0000000102 | BioModels | 2006-04-20
REPOSITORIES: BioModels
Publications
Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability.
Legewie Stefan S Blüthgen Nils N Herzel Hanspeter H
PLoS computational biology 20060728 9
The intrinsic, or mitochondrial, pathway of caspase activation is essential for apoptosis induction by various stimuli including cytotoxic stress. It depends on the cellular context, whether cytochrome c released from mitochondria induces caspase activation gradually or in an all-or-none fashion, and whether caspase activation irreversibly commits cells to apoptosis. By analyzing a quantitative kinetic model, we show that inhibition of caspase-3 (Casp3) and Casp9 by inhibitors of apoptosis (IAPs ...[more]
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For more information see the terms of use
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