Dataset Information

Clarke2006_Smad_signalling

ABSTRACT: The model reproduces the temporal evolution of four variables depicted in Fig 2a. The solution is generated for median parameter values as given in Table 3. Result shown was generated by MathSBML. This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2010 The BioModels.net Team. For more information see the terms of use . To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Katja Wegner

PROVIDER: BIOMD0000000112 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:

			Action	DRS
	BIOMD0000000112?filename=BIOMD0000000112-biopax2.owl	Owl
	BIOMD0000000112?filename=BIOMD0000000112-biopax3.owl	Owl
	BIOMD0000000112?filename=BIOMD0000000112-matlab.m	Other
	BIOMD0000000112?filename=BIOMD0000000112-octave.m	Other
	BIOMD0000000112?filename=BIOMD0000000112.m	Other

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Publications

Systems theory of Smad signalling.

Clarke D C DC Betterton M D MD Liu X X

Systems biology 20061101 6

Transforming growth factor-beta (TGFbeta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGFbeta signalling are the Smad proteins, which upon TGFbeta stimulation accumulate in the nucleus and regulate the transcription of target genes. To investigate the mechanisms of Smad nuclear accumulation, we developed a simple mathematical model of canonical Smad signalling. The model was built using both published data and our experime ...[more]

PMID: 17186703

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