Ontology highlight
ABSTRACT:
REANALYSIS of: BIOMD0000000010BIOMD0000000019BIOMD0000000048
REANALYSED by: BIOMD0000000441BIOMD0000000223BIOMD0000000440BIOMD0000000424BIOMD0000000049
SUBMITTER: Enuo He
PROVIDER: BIOMD0000000146 | BioModels | 2008-07-16
REPOSITORIES: BioModels
Moehren Gisela G Markevich Nick N Demin Oleg O Kiyatkin Anatoly A Goryanin Igor I Hoek Jan B JB Kholodenko Boris N BN
Biochemistry 20020101 1
Stimulation of isolated hepatocytes with epidermal growth factor (EGF) causes rapid tyrosine phosphorylation of the EGF receptor (EGFR) and adapter/target proteins, which was monitored with 1 and 2 s resolution at 37, 20, and 4 degrees C. The temporal responses detected for multiple signaling proteins involve both transient and sustained phosphorylation patterns, which change dramatically at low temperatures. To account quantitatively for complex responses, we employed a mechanistic kinetic mode ...[more]