Ontology highlight
ABSTRACT:
SUBMITTER: Enuo He
PROVIDER: BIOMD0000000146 | BioModels | 2008-07-16
REPOSITORIES: BioModels
Hatakeyama Mariko M Kimura Shuhei S Naka Takashi T Kawasaki Takuji T Yumoto Noriko N Ichikawa Mio M Kim Jae-Hoon JH Saito Kazuki K Saeki Mihoro M Shirouzu Mikako M Yokoyama Shigeyuki S Konagaya Akihiko A
The Biochemical journal 20030701 Pt 2
ErbB tyrosine kinase receptors mediate mitogenic signal cascade by binding a variety of ligands and recruiting the different cassettes of adaptor proteins. In the present study, we examined heregulin (HRG)-induced signal transduction of ErbB4 receptor and found that the phosphatidylinositol 3'-kinase (PI3K)-Akt pathway negatively regulated the extracellular signal-regulated kinase (ERK) cascade by phosphorylating Raf-1 on Ser(259). As the time-course kinetics of Akt and ERK activities seemed to ...[more]