Ontology highlight
ABSTRACT:
SUBMITTER: Harish Dharuri
PROVIDER: BIOMD0000000157 | BioModels | 2008-01-10
REPOSITORIES: BioModels
Molecular systems biology 20060613
Understanding the dynamics and variability of protein circuitry requires accurate measurements in living cells as well as theoretical models. To address this, we employed one of the best-studied protein circuits in human cells, the negative feedback loop between the tumor suppressor p53 and the oncogene Mdm2. We measured the dynamics of fluorescently tagged p53 and Mdm2 over several days in individual living cells. We found that isogenic cells in the same environment behaved in highly variable w ...[more]