Ontology highlight
ABSTRACT:
SUBMITTER: Harish Dharuri
PROVIDER: BIOMD0000000170 | BioModels | 2008-04-16
REPOSITORIES: BioModels
Becker-Weimann Sabine S Wolf Jana J Herzel Hanspeter H Kramer Achim A
Biophysical journal 20040903 5
The suprachiasmatic nucleus governs daily variations of physiology and behavior in mammals. Within single neurons, interlocked transcriptional/translational feedback loops generate circadian rhythms on the molecular level. We present a mathematical model that reflects the essential features of the mammalian circadian oscillator to characterize the differential roles of negative and positive feedback loops. The oscillations that are obtained have a 24-h period and are robust toward parameter vari ...[more]