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Weimann2004_CircadianOscillator


ABSTRACT: The model reproduces the time profile of the species as depicted in Fig 3A of the paper. Model successfully tested on MathSBML and Jarnac.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000170 | BioModels | 2008-04-16

REPOSITORIES: BioModels

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Publications

Modeling feedback loops of the Mammalian circadian oscillator.

Becker-Weimann Sabine S   Wolf Jana J   Herzel Hanspeter H   Kramer Achim A  

Biophysical journal 20040903 5


The suprachiasmatic nucleus governs daily variations of physiology and behavior in mammals. Within single neurons, interlocked transcriptional/translational feedback loops generate circadian rhythms on the molecular level. We present a mathematical model that reflects the essential features of the mammalian circadian oscillator to characterize the differential roles of negative and positive feedback loops. The oscillations that are obtained have a 24-h period and are robust toward parameter vari  ...[more]

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