ABSTRACT:
Leloup and Goldbeter, 1998
This model was created after the article by Leloup and Goldbeter, J Biol Rhythms
1998, Vol:13(1),pp70-87, pubmedID: 9486845
A Model for Circadian Rhythms in Drosophila
Incorporating the Formation of a Complex between the PER and TIM Proteins
The parameters and initial concentrations are taken to reproduce figs. 4 D,E,F in the publication.
For a simulation without light dependent degradation of TIM_pp, change the the parameter v_dT_fac
to 1.
The light/dark phases length can be set using the parameter l_d
.
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for more information.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Lukas Endler 