Models

Dataset Information

0

Birtwistle2007_ErbB_Signalling

ABSTRACT: This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team.For more information see the terms of use.To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

SUBMITTER: Molecular Systems Biology  

PROVIDER: BIOMD0000000175 | BioModels | 2008-07-17

REPOSITORIES: BioModels

Json Xml
altmetric image

Publications

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses.

Birtwistle Marc R MR   Hatakeyama Mariko M   Yumoto Noriko N   Ogunnaike Babatunde A BA   Hoek Jan B JB   Kholodenko Boris N BN  

Molecular systems biology 20071113

Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes how stimulation of all four ErbB receptors with epidermal growth factor (EGF) and heregulin (HRG) leads to activation of two critical downstream proteins, extracellular-signal-regulated kinase (ERK) and Akt. Model analysis and experimental validat  ...[more]

Similar Datasets

Models Leloup1999_CircClock
2005-06-29 | BIOMD0000000021 | BioModels
Models Smolen2002_CircClock
2005-06-29 | BIOMD0000000025 | BioModels
Models Bray1995_chemotaxis_receptorlinkedcomplex
2008-11-07 | BIOMD0000000200 | BioModels
Models Goldbeter1990_CalciumSpike_CICR
2007-03-21 | BIOMD0000000098 | BioModels
Models Blum2000_LHsecretion_1
2006-11-09 | BIOMD0000000077 | BioModels
Models Leloup2003_CircClock_DD_REV-ERBalpha
2006-10-19 | BIOMD0000000074 | BioModels
Models Meyer1991_CalciumSpike_ICC
2009-08-05 | BIOMD0000000224 | BioModels
Models Markevich2004_MAPK_AllRandomElementary
2005-05-26 | BIOMD0000000030 | BioModels
Models Izhikevich2004_SpikingNeurons_subthresholdOscillations
2007-07-16 | BIOMD0000000135 | BioModels
Models Izhikevich2004_SpikingNeurons_Class2Excitable
2007-07-16 | BIOMD0000000142 | BioModels