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Sriram2007_CellCycle


ABSTRACT: The model reproduces the time profile of species depicted in Figure 12a and 12 b. The authors communicated to the curator that there is a typo in the paper, the values of kd1 and kd2 are reversed. Model successfully reproduced using MathSBML.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000181 | BioModels | 2008-08-12

REPOSITORIES: BioModels

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Publications

A minimal mathematical model combining several regulatory cycles from the budding yeast cell cycle.

Sriram K K   Bernot G G   Képès F F  

IET systems biology 20071101 6


A novel topology of regulatory networks abstracted from the budding yeast cell cycle is studied by constructing a simple nonlinear model. A ternary positive feedback loop with only positive regulations is constructed with elements that activates the subsequent element in a clockwise fashion. A ternary negative feedback loop with only negative regulations is constructed with the elements that inhibit the subsequent element in an anticlockwise fashion. Positive feedback loop exhibits bistability,  ...[more]

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