Ontology highlight
ABSTRACT:
SUBMITTER: Bashar Ibrahim
PROVIDER: BIOMD0000000193 | BioModels | 2008-11-27
REPOSITORIES: BioModels
Ibrahim Bashar B Schmitt Eberhard E Dittrich Peter P Diekmann Stephan S
Bio Systems 20080712 1
Eukaryotic cells rely on a surveillance mechanism, the "Spindle Assembly Checkpoint"SACM in order to ensure accurate chromosome segregation by preventing anaphase initiation until all chromosomes are correctly attached to the mitotic spindle. In different organisms, a mitotic checkpoint complex (MCC) composed of Mad2, Bub3, BubR1/Mad3, and Cdc20 inhibits the anaphase promoting complex (APC/C) to initiate promotion into anaphase. The mechanism of MCC formation and its regulation by the kinetochor ...[more]