Ontology highlight
ABSTRACT:
SUBMITTER: Bashar Ibrahim
PROVIDER: BIOMD0000000194 | BioModels | 2008-09-11
REPOSITORIES: BioModels
Ibrahim Bashar B Dittrich Peter P Diekmann Stephan S Schmitt Eberhard E
Biophysical chemistry 20080206 1-2
For successful mitosis, metaphase has to be arrested until all centromeres are properly attached. The onset of anaphase, which is initiated by activating the APC, is controlled by the spindle assembly checkpoint (M)SAC. Mad2, which is a constitutive member of the (M)SAC, is supposed to inhibit the activity of the APC by sequestering away its co-activator Cdc20. Mad1 recruits Mad2 to unattached kinetochores and is compulsory for the establishment of the Mad2 and Cdc20 complexes. Recently, based o ...[more]