Models

Dataset Information

0

Ibrahim2008_Cdc20_Sequestring_Template_Model


ABSTRACT: Biophysical Chemistry 134 (2008) 93-100 Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study) Bashar Ibrahim, Peter Dittrich, Stephan Diekmann, Eberhard Schmitt This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2009 The BioModels Team. For more information see the terms of use . To cite BioModels Database, please use Le Novère N., Bornstein B., Broicher A., Courtot M., Donizelli M., Dharuri H., Li L., Sauro H., Schilstra M., Shapiro B., Snoep J.L., Hucka M. (2006) BioModels Database: A Free, Centralized Database of Curated, Published, Quantitative Kinetic Models of Biochemical and Cellular Systems Nucleic Acids Res., 34: D689-D691.

SUBMITTER: Bashar Ibrahim  

PROVIDER: BIOMD0000000194 | BioModels | 2008-09-11

REPOSITORIES: BioModels

altmetric image

Publications

Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study).

Ibrahim Bashar B   Dittrich Peter P   Diekmann Stephan S   Schmitt Eberhard E  

Biophysical chemistry 20080206 1-2


For successful mitosis, metaphase has to be arrested until all centromeres are properly attached. The onset of anaphase, which is initiated by activating the APC, is controlled by the spindle assembly checkpoint (M)SAC. Mad2, which is a constitutive member of the (M)SAC, is supposed to inhibit the activity of the APC by sequestering away its co-activator Cdc20. Mad1 recruits Mad2 to unattached kinetochores and is compulsory for the establishment of the Mad2 and Cdc20 complexes. Recently, based o  ...[more]

Similar Datasets

2008-09-01 | BIOMD0000000187 | BioModels
2008-09-02 | BIOMD0000000186 | BioModels
2008-11-27 | BIOMD0000000193 | BioModels
2012-02-09 | BIOMD0000000702 | BioModels
2012-02-09 | BIOMD0000000699 | BioModels
2005-01-01 | BIOMD0000000701 | BioModels
| 196 | FAIRDOMHub
| PRJNA402580 | ENA
2019-01-12 | GSE93553 | GEO
| PRJEB4451 | ENA