Ontology highlight
ABSTRACT:
SUBMITTER: Harish Dharuri
PROVIDER: BIOMD0000000196 | BioModels | 2008-10-13
REPOSITORIES: BioModels
Srividhya J J Gopinathan M S MS
Journal of theoretical biology 20060213 3
We propose a seven variable model with time delay in one of the variables for the cell cycle in higher eukaryotes. The model consists of four important phosphorylation-dephosphorylation (P-D) cycles that govern the cell cycle, namely Pre-MPF-MPF, Cdc25P-Cdc25, Wee1P-Wee1 and APCP-APC. Other variables are cyclin, free cyclin dependent kinase (Cdk) and mass. The mass acts as a G2/M checkpoint and the checkpoint is represented by a saddle node loop bifurcation. The key feature of the model is that ...[more]