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Bartholome2007_MDCKII


ABSTRACT: SBML model exported from PottersWheel on 2007-09-19 15:35:47. The values for parameters and the inital concentrations of this model where directly provided by the main author: Parameter values parameter value unit p1 0.0025 1/min p2 0.0784 1/min p3 0.0013 1/min p4 0.0827 1/min p5 0.0091 1/min p6 0.000064 1/(nmole*min) p7 0.0397 1/min p8 1000 nmole p9 0.0098 1/(nmole*min) p10 1.6 1/min p11 1000 nmole p12 0.0003 ml/min The basal chamber volume was taken as 1 ml, the apical as 1.5. As starting values x1 was set to 88 nmole, all other species to 0. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Kilian Bartholomé  

PROVIDER: BIOMD0000000197 | BioModels | 2008-09-25

REPOSITORIES: BioModels

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Publications

Data-based mathematical modeling of vectorial transport across double-transfected polarized cells.

Bartholomé Kilian K   Rius Maria M   Letschert Katrin K   Keller Daniela D   Timmer Jens J   Keppler Dietrich D  

Drug metabolism and disposition: the biological fate of chemicals 20070604 9


Vectorial transport of endogenous small molecules, toxins, and drugs across polarized epithelial cells contributes to their half-life in the organism and to detoxification. To study vectorial transport in a quantitative manner, an in vitro model was used that includes polarized MDCKII cells stably expressing the recombinant human uptake transporter OATP1B3 in their basolateral membrane and the recombinant ATP-driven efflux pump ABCC2 in their apical membrane. These double-transfected cells enabl  ...[more]

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