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Goldbeter2008_Somite_Segmentation_Clock_Notch_Wnt_FGF


ABSTRACT: This is a model of the coupled Natch, Wnt and FGF modules as described in: A. Goldbeter and O. Pourquié , Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways. J Theor Biol. 2008 Jun 7;252(3):574-85, pubmed ID: 18308339 To uncouple the modules remove the reaction MAx_trans_Xa and set vsFK=vsF . The SBML version of the model was converted from the CellML version by Catherine Lloyd for the CellML repository . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Lukas Endler  

PROVIDER: BIOMD0000000201 | BioModels | 2008-11-07

REPOSITORIES: BioModels

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Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways.

Goldbeter Albert A   Pourquié Olivier O  

Journal of theoretical biology 20080118 3


The formation of somites in the course of vertebrate segmentation is governed by an oscillator known as the segmentation clock, which is characterized by a period ranging from 30 min to a few hours depending on the organism. This oscillator permits the synchronized activation of segmentation genes in successive cohorts of cells in the presomitic mesoderm in response to a periodic signal emitted by the segmentation clock, thereby defining the future segments. Recent microarray experiments [Dequea  ...[more]

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