Dataset Information

Decroly1982_Enzymatic_Oscillator

ABSTRACT: This is the scaled model described in the article: Birhythmicity, chaos, and other patterns of temporal self-organization in a multiply regulated biochemical system Olivier Decroly, Albert Goldbeter, Proc Natl Acad Sci USA 1982 79:6917-6921; PMID:6960354; Abstract: We analyze on a model biochemical system the effect of a coupling between two instability-generating mechanisms. The system considered is that of two allosteric enzymes coupled in series and activated by their respective products. In addition to simple periodic oscillations, the system can exhibit a variety of new modes of dynamic behavior; coexistence between two stable periodic regimes (birhythmicity), random oscillations (chaos), and coexistence of a stable periodic regime with a stable steady state (hard excitation) or with chaos. The relationship between these patterns of temporal self-organization is analyzed as a function of the control parameters of the model. Chaos and birhythmicity appear to be rare events in comparison with simple periodic behavior. We discuss the relevance of these results with respect to the regularity of most biological rhythms. The parameters q1 = 50 and q2 = 0.02 are explicitely included as the stoichiometric coefficients of beta and gamma in the reactions r2 and r3, respectively. Parameter values and initial conditions [ks=1.99/sec, alpha(0)=29.19988, beta(0)=188.8, gamma(0)=0.3367] are for the chaotic regime presented in the upper-curve of Figure 3b.

SUBMITTER: Kieran Smallbone

PROVIDER: BIOMD0000000319 | BioModels | 2010-08-11

REPOSITORIES: BioModels

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Publications

Birhythmicity, chaos, and other patterns of temporal self-organization in a multiply regulated biochemical system.

Decroly O O Goldbeter A A

Proceedings of the National Academy of Sciences of the United States of America 19821101 22

We analyze on a model biochemical system the effect of a coupling between two instability-generating mechanisms. The system considered is that of two allosteric enzymes coupled in series and activated by their respective products. In addition to simple periodic oscillations, the system can exhibit a variety of new modes of dynamic behavior; coexistence between two stable periodic regimes (birhythmicity), random oscillations (chaos), and coexistence of a stable periodic regime with a stable stead ...[more]

PMID: 6960354

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Dataset Information

Decroly1982_Enzymatic_Oscillator

Publications

Birhythmicity, chaos, and other patterns of temporal self-organization in a multiply regulated biochemical system.

Similar Datasets

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