Dataset Information

Abell2011_CalciumSignaling_WithoutAdaptation

ABSTRACT: This model is from the article: Parallel adaptive feedback enhances reliability of the Ca2+ signaling system. Abell E, Ahrends R, Bandara S, Park BO, Teruel MN. Proc Natl Acad Sci U S A. 2011 Aug 15. 21844332 , Abstract: Despite large cell-to-cell variations in the concentrations of individual signaling proteins, cells transmit signals correctly. This phenomenon raises the question of what signaling systems do to prevent a predicted high failure rate. Here we combine quantitative modeling, RNA interference, and targeted selective reaction monitoring (SRM) mass spectrometry, and we show for the ubiquitous and fundamental calcium signaling system that cells monitor cytosolic and endoplasmic reticulum (ER) Ca(2+) levels and adjust in parallel the concentrations of the store-operated Ca(2+) influx mediator stromal interaction molecule (STIM), the plasma membrane Ca(2+) pump plasma membrane Ca-ATPase (PMCA), and the ER Ca(2+) pump sarco/ER Ca(2+)-ATPase (SERCA). Model calculations show that this combined parallel regulation in protein expression levels effectively stabilizes basal cytosolic and ER Ca(2+) levels and preserves receptor signaling. Our results demonstrate that, rather than directly controlling the relative level of signaling proteins in a forward regulation strategy, cells prevent transmission failure by sensing the state of the signaling pathway and using multiple parallel adaptive feedbacks. Note: There are two models described in the paper to simulate basal and receptor stimulated Ca 2+ signaling. 1) No adaptive feedback (this model: MODEL1108050000) and 2) with three slow adaptive feedback loops (MODEL1108050001).

SUBMITTER: Samuel Bandara

PROVIDER: BIOMD0000000354 | BioModels | 2011-08-17

REPOSITORIES: BioModels

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Publications

Parallel adaptive feedback enhances reliability of the Ca2+ signaling system.

Abell Ellen E Ahrends Robert R Bandara Samuel S Park Byung Ouk BO Teruel Mary N MN

Proceedings of the National Academy of Sciences of the United States of America 20110815 35

Despite large cell-to-cell variations in the concentrations of individual signaling proteins, cells transmit signals correctly. This phenomenon raises the question of what signaling systems do to prevent a predicted high failure rate. Here we combine quantitative modeling, RNA interference, and targeted selective reaction monitoring (SRM) mass spectrometry, and we show for the ubiquitous and fundamental calcium signaling system that cells monitor cytosolic and endoplasmic reticulum (ER) Ca(2+) l ...[more]

PMID: 21844332

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Project description:Wang2007 - ATP induced intracellular Calicum Oscillation The model simulate the ATP-induced intracellular Ca2+ oscillations and the quantitative effect of ATP concentration on the oscillation characteristics such as the duration, peak concentration of intracellular Ca2+ and average interval. This model is described in the article: A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations. Wang J, Huang X, Huang W. J. Theor. Biol. 2007 Apr; 245(3): 510-519 Abstract: A quantitative kinetic model is proposed to simulate the ATP-induced intracellular Ca(2+) oscillations. The quantitative effect of ATP concentration upon the oscillations was successfully simulated. Our simulation results support previous experimental explanations that the Ca(2+) oscillations are mainly due to interaction of Ca(2+) release from the endoplasmic reticulum (ER) and the ATP-dependent Ca(2+) pump back into the ER, and the oscillations are prolonged by extracellular Ca(2+) entry that maintains the constant Ca(2+) supplies to its intracellular stores. The model is also able to simulate the sudden disappearance phenomenon of the Ca(2+) oscillations observed in some cell types by taking into account of the biphasic characteristic of the Ca(2+) release from the endoplasmic reticulum (ER). Moreover, the model simulation results for the Ca(2+) oscillations characteristics such as duration, peak [Ca(2+)](cyt), and average interval, etc., lead to prediction of some possible factors responsible for the variations of Ca(2+) oscillations in different types of cells. This model is hosted on BioModels Database and identified by: BIOMD0000000145. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Dataset Information

Abell2011_CalciumSignaling_WithoutAdaptation

Publications

Parallel adaptive feedback enhances reliability of the Ca2+ signaling system.

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