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Butenas2004_BloodCoagulation

ABSTRACT: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Michael Schubert

PROVIDER: BIOMD0000000362 | BioModels | 2011-08-26

REPOSITORIES: BioModels

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The significance of circulating factor IXa in blood.

Butenas Saulius S Orfeo Thomas T Gissel Matthew T MT Brummel Kathleen E KE Mann Kenneth G KG

The Journal of biological chemistry 20040323 22

The presence of activation peptides (AP) of the vitamin K-dependent proteins in the phlebotomy blood of human subjects suggests that active serine proteases may circulate in blood as well. The goal of the current study was to evaluate the influence of trace amounts of key coagulation proteases on tissue factor-independent thrombin generation using three models of coagulation. With procoagulants and select coagulation inhibitors at mean physiological concentrations, concentrations of factor IXa, ...[more]

PMID: 15039440

Publication: 1/3

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