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Mueller2008_ThrombinGeneration_minimal

ABSTRACT: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. For more information see the terms of use. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

DISEASE(S): Coronary Artery Disease

SUBMITTER: Michael Schubert

PROVIDER: BIOMD0000000367 | BioModels | 2011-05-16

REPOSITORIES: BioModels

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Tolerance and threshold in the extrinsic coagulation system.

Müller Johannes J Brandt Stefan S Mayerhofer Katrin K Tjardes Thorsten T Maegele Marc M

Mathematical biosciences 20070814 2

This paper focus on the quest for mechanisms that are able to create tolerance and an activation threshold in the extrinsic coagulation cascade. We propose that the interplay of coagulation inhibitor and blood flow creates threshold behavior. First we test this hypothesis in a minimal, four dimensional model. This model can be analysed by means of time scale analysis. We find indeed that only the interplay of blood flow and inhibition together are able to produce threshold behavior. The mechanis ...[more]

PMID: 17936855

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