Dataset Information

Mol2013 - Immune Signal Transduction in Leishmaniasis

ABSTRACT: Created by The MathWorks, Inc. SimBiology tool, Version 3.3

DISEASE(S): Leishmaniasis

SUBMITTER: Shailza Singh

PROVIDER: BIOMD0000000477 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:

			Action	DRS
	BIOMD0000000477?filename=BIOMD0000000477-biopax2.owl	Owl
	BIOMD0000000477?filename=BIOMD0000000477-biopax3.owl	Owl
	BIOMD0000000477?filename=BIOMD0000000477-matlab.m	Other
	BIOMD0000000477?filename=BIOMD0000000477-octave.m	Other
	BIOMD0000000477?filename=BIOMD0000000477.m	Other

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Publications

Immune signal transduction in leishmaniasis from natural to artificial systems: role of feedback loop insertion.

Mol Milsee M Patole Milind S MS Singh Shailza S

Biochimica et biophysica acta 20130830 1

<h4>Background</h4>Modulated immune signal (CD14-TLR and TNF) in leishmaniasis can be linked to EGFR pathway involved in wound healing, through crosstalk points. This signaling network can be further linked to a synthetic gene circuit acting as a positive feedback loop to elicit a synchronized intercellular communication among the immune cells which may contribute to a better understanding of signaling dynamics in leishmaniasis.<h4>Methods</h4>Network reconstruction with positive feedback loop, ...[more]

PMID: 23994140

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