Dataset Information
Sharp2013 - Lipopolysaccharide induced NFkB activation
Ontology highlight
ABSTRACT:
SUBMITTER: 
Gemma Sharp
PROVIDER: BIOMD0000000489 | BioModels | 2013-09-24
REPOSITORIES: BioModels
Publications
A computational model of lipopolysaccharide-induced nuclear factor kappa B activation: a key signalling pathway in infection-induced preterm labour.
PloS one 20130730 7
Preterm birth is the single biggest cause of significant neonatal morbidity and mortality, and the incidence is rising. Development of new therapies to treat and prevent preterm labour is seriously hampered by incomplete understanding of the molecular mechanisms that initiate labour at term and preterm. Computational modelling provides a new opportunity to improve this understanding. It is a useful tool in (i) identifying gaps in knowledge and informing future research, and (ii) providing the ba ...[more]
