Hermansen2015 - denovo biosynthesis of pyrimidines in yeast

ABSTRACT: Hermansen2015 - denovo biosynthesis of pyrimidines in yeast This model is described in the article: Characterizing selective pressures on the pathway for de novo biosynthesis of pyrimidines in yeast. Hermansen RA , Mannakee BK , Knecht W , Liberles DA , Gutenkunst RN BMC Evolutionary Biology. 2015, 15:232 Abstract: Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individual protein-encoding genes.Gene families across yeast were constructed for each member of the pathway and the ratio of nonsynonymous to synonymous nucleotide substitution rates (dN/dS) was estimated for each enzyme from S. cerevisiae and closely related species. We found a positive relationship between the influence that each enzyme has on pathway function and its selective constraint.We expect this trend to be locally present for enzymes that have pathway control, but over longer evolutionary timescales we expect that mutation-selection balance may change the enzymes that have pathway control. This model is hosted on BioModels Database and identified by: MODEL1512160000. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Brian Mannakee  

PROVIDER: BIOMD0000000590 | BioModels | 2015-12-10

REPOSITORIES: BioModels