Project description:We report that IFI16, which was previously identified as a cytosolic DNA sensor, is essential for the activation of programmed cell death pathways in IAV infected cells. We have identified IFI16 as an innate immune sensor of the influenza A virus. We find that IFI16 recognizes viral genomic RNA upon infection. The activation of IFI16, in turn, triggers the production of type I, III interferons, and also other pro-inflammatory cytokines via the STING-TBK1 and Pro-caspase-1 signalling axis, thereby promoting cell death (apoptosis and pyroptosis in IAV infected cells).

2021-12-31 | GSE163705 | GEO

Modelling the Innate Immune Response against Avian Influenza Virus in Chicken.

Project description: Not available

| S-EPMC4915690 | biostudies-literature

NMP4 regulates the innate immune response to influenza A virus infection.

Project description: Not available

| S-EPMC7483155 | biostudies-literature

Mini viral RNAs act as innate immune agonists during influenza virus infection.

Project description: Not available

| S-EPMC6203953 | biostudies-literature

Novel influenza virus NS1 antagonists block replication and restore innate immune function.

Project description: Not available