Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Aston2018 - Dynamics of Hepatitis C Infection

ABSTRACT: No description

SUBMITTER: Sarubini Kananathan

PROVIDER: BIOMD0000000713 | BioModels | 2018-10-16

REPOSITORIES: BioModels

ACCESS DATA

Json Xml

Publications

A New Model for the Dynamics of Hepatitis C Infection: Derivation, Analysis and Implications.

Aston Philip J PJ

Viruses 20180413 4

We review various existing models of hepatitis C virus (HCV) infection and show that there are inconsistencies between the models and known behaviour of the infection. A new model for HCV infection is proposed, based on various dynamical processes that occur during the infection that are described in the literature. This new model is analysed, and three steady state branches of solutions are found when there is no stem cell generation of hepatocytes. Unusually, the branch of infected solutions t ...[more]

PMID: 29652855

Similar Datasets

Dynamics of the Immune Response in Acute Hepatitis B Infection.

Project description: Not available

| S-EPMC5739046 | biostudies-literature

Longitudinal transcriptomic characterization of the immune response to acute hepatitis C virus infection

Project description:Most individuals exposed to hepatitis C virus (HCV) become persistently infected while a minority spontaneously eliminate the virus. Although early immune events influence infection outcome, the cellular composition, molecular effectors, and timeframe of the host response active shortly after viral exposure remain incompletely understood. Employing specimens collected from people who inject drugs (PWID) with high risk of HCV exposure, we utilized RNA-Seq to characterize immune function in peripheral blood before, during, and after acute HCV infection resulting in spontaneous resolution. Our results provide a detailed description of innate immune programs active in peripheral blood during acute HCV infection, which include prominent type I interferon and inflammatory signatures. Innate immune gene expression rapidly returns to pre-infection levels upon viral clearance. This innate response coincides with a decrease in B cell transcriptional signatures. These results represent the first longitudinal transcriptomic characterization of human immune function in acute HCV infection and identify several dynamically regulated features of the complex response to natural HCV exposure.

2018-08-29 | GSE119117 | GEO

Dynamics of HCV RNA levels during acute hepatitis C virus infection.

Project description: Not available

| S-EPMC4276420 | biostudies-literature

Exceptional Heterogeneity in Viral Evolutionary Dynamics Characterises Chronic Hepatitis C Virus Infection.

Project description: Not available

| S-EPMC5025083 | biostudies-literature

Association Between Hepatitis C Infection and Renal Cell Carcinoma

Project description:The purpose of this study is to determine if there is an association between hepatitis C infection and kidney cancer. All patients who are diagnosed with kidney cancer and who will either have a biopsy or surgery will be offered to be tested for hepatitis C. The control group will be colon cancer patients. Both groups would be of recent diagnosis (6 months).

| 2110600 | ecrin-mdr-crc

Schistosomiasis, hepatitis B and hepatitis C co-infection.

Project description: Not available

| S-EPMC4323254 | biostudies-other

The role of cells refractory to productive infection in acute hepatitis B viral dynamics.

Project description: Not available

| S-EPMC1829262 | biostudies-literature

Molecular Signature of Hepatitis D Virus-Associated Hepatocellular Carcinoma

Project description:To investigate the role of viral and host factors in HDV-associated HCC we carried out an integrated clinicopathological and gene expression study of tissue specimens and laser microdissected hepatocytes obtained at the time of liver transplantation from livers with HDV-HCC, HDV-cirrhosis without HCC, HCV-HCC and HBV-HCC. References to GSM series of HDV and HBV livers, already deposited in GEO, are included in this series. Part of data of HCV livers are a re-analysis of GSE series GSE69715 and GSE78737, the re-analyzed GSM is indicated in the 'description' column and with a link at the bottom of the page.

2018-04-09 | GSE107170 | GEO

Epidemic history and evolutionary dynamics of hepatitis B virus infection in two remote communities in rural Nigeria.

Project description: Not available

| S-EPMC2906510 | biostudies-literature

Effect of SARS-CoV-2 coinfection was not apparent on the dynamics of chronic hepatitis B infection.

Project description: Not available

| S-EPMC7698656 | biostudies-literature