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Panteleev2010 - Blood Coagulation: Full Model

ABSTRACT: Full and reduced mathematical model of blood coagulation focusing on fibrin formation and the response to varied TF and V.

SUBMITTER: Matthew Roberts

PROVIDER: BIOMD0000000740 | BioModels | 2019-07-05

REPOSITORIES: BioModels

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Task-oriented modular decomposition of biological networks: trigger mechanism in blood coagulation.

Panteleev Mikhail A MA Balandina Anna N AN Lipets Elena N EN Ovanesov Mikhail V MV Ataullakhanov Fazoil I FI

Biophysical journal 20100501 9

Analysis of complex time-dependent biological networks is an important challenge in the current postgenomic era. We propose a middle-out approach for decomposition and analysis of complex time-dependent biological networks based on: 1), creation of a detailed mechanism-driven mathematical model of the network; 2), network response decomposition into several physiologically relevant subtasks; and 3), subsequent decomposition of the model, with the help of task-oriented necessity and sensitivity a ...[more]

PMID: 20441738

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