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Cappuccio2006 - Cancer immunotherapy by interleukin-21

ABSTRACT: This model describes the effects of Il-21 on tumor eradication via natural killer cell-mediated and CD8+ T-cell-mediated lysis of tumor cells. The model demonstrates changes in growth dynamics in nonimmunogenic B16 melanoma and the immunogenic MethA and MCA205 fibrosarcomas, showing a strong dependence of the NK-cell/CD8+ T-cell balance on tumor immunogenicity.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000761 | BioModels | 2019-07-26

REPOSITORIES: BioModels

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Cancer immunotherapy by interleukin-21: potential treatment strategies evaluated in a mathematical model.

Cappuccio Antonio A Elishmereni Moran M Agur Zvia Z

Cancer research 20060701 14

The newly characterized interleukin (IL)-21 plays a central role in the transition from innate immunity to adaptive immunity and shows substantial tumor regression in mice. IL-21 is now developed as a cancer immunotherapeutic drug, but conditions for efficacious therapy, and the conflicting immunostimulatory and immunoinhibitory influence of the cytokine, are yet to be defined. We studied the effects of IL-21 on tumor eradication in a mathematical model focusing on natural killer (NK) cell-media ...[more]

PMID: 16849579

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