Cappuccio2006 - Cancer immunotherapy by interleukin-21

ABSTRACT: This model describes the effects of Il-21 on tumor eradication via natural killer cell-mediated and CD8+ T-cell-mediated lysis of tumor cells. The model demonstrates changes in growth dynamics in nonimmunogenic B16 melanoma and the immunogenic MethA and MCA205 fibrosarcomas, showing a strong dependence of the NK-cell/CD8+ T-cell balance on tumor immunogenicity.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000761 | BioModels | 2024-09-02

REPOSITORIES: BioModels