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Dritschel2018 - A mathematical model of cytotoxic and helper T cell interactions in a tumour microenvironment

ABSTRACT: This model examines the role of helper and cytotoxic T cells in an anti-tumour response, with implicit inclusions of immunosuppressive effects. The model demonstrates the dependence of immunoediting on infilftration by helper and cytotoxic T cells, as well as the importance of these cells in mediating tumour elimination.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000763 | BioModels | 2019-12-18

REPOSITORIES: BioModels

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Publications

Nonlinear dynamics of immunogenic tumors: parameter estimation and global bifurcation analysis.

Kuznetsov V A VA Makalkin I A IA Taylor M A MA Perelson A S AS

Bulletin of mathematical biology 19940301 2

We present a mathematical model of the cytotoxic T lymphocyte response to the growth of an immunogenic tumor. The model exhibits a number of phenomena that are seen in vivo, including immunostimulation of tumor growth, "sneaking through" of the tumor, and formation of a tumor "dormant state". The model is used to describe the kinetics of growth and regression of the B-lymphoma BCL1 in the spleen of mice. By comparing the model with experimental data, numerical estimates of parameters describing ...[more]

PMID: 8186756

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