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ABSTRACT: A mathematical model describing oncolytic virotherapy with incorporation the viral lytic cycle and the virus-specific CTL response. The thresholds for viral treatment and virus-specific CTl response are also obtained.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000772 | BioModels | 2019-08-01


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A mathematical model of oncolytic virotherapy with time delay.

Wang Zi Zi ZZ   Guo Zhi Ming ZM   Smith Hal H  

Mathematical biosciences and engineering : MBE 20190301 4

Oncolytic virotherapy is an emerging treatment modality which uses replication-competent viruses to destroy cancers without causing harm to normal tissues. By the development of molecular biotechnology, many effective viruses are adapted or engineered to make them cancer-specific, such as measles, adenovirus, herpes simplex virus and M1 virus. A successful design of virus needs a full understanding about how viral and host parameters influence the tumor load. In this paper, we propose a mathemat  ...[more]

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