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Dong2014 - Mathematical modeling on helper t cells in a tumor immune system

ABSTRACT: This model gives a mathematical description of the interactions between tumor cells, cytotoxic T lymphocytes and helper T cells (HTCs) within the tumor microenvironment, with emphasis on the role played by HTCs. The effects and dynamics of adoptive cell immunotherapy and HTC recruitment are also specifically discussed.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000783 | BioModels | 2019-12-18


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Nonlinear dynamics of immunogenic tumors: parameter estimation and global bifurcation analysis.

Kuznetsov V A VA   Makalkin I A IA   Taylor M A MA   Perelson A S AS  

Bulletin of mathematical biology 19940301 2

We present a mathematical model of the cytotoxic T lymphocyte response to the growth of an immunogenic tumor. The model exhibits a number of phenomena that are seen in vivo, including immunostimulation of tumor growth, "sneaking through" of the tumor, and formation of a tumor "dormant state". The model is used to describe the kinetics of growth and regression of the B-lymphoma BCL1 in the spleen of mice. By comparing the model with experimental data, numerical estimates of parameters describing  ...[more]

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