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Lopez2014 - A Validated Mathematical Model of Tumor Growth Including Tumor-Host Interaction and Cell-Mediated Immune Response

ABSTRACT: This is a dynamical model of cancer growth that includes three interacting cell populations of tumor cells, healthy host cells and immune effector cells. The tumor-immune and the tumor-host interactions are characterized to reproduce experimental results.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000784 | BioModels | 2021-10-01

REPOSITORIES: BioModels

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A validated mathematical model of tumor growth including tumor-host interaction, cell-mediated immune response and chemotherapy.

López Alvaro G AG Seoane Jesús M JM Sanjuán Miguel A F MA

Bulletin of mathematical biology 20141028 11

We consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. The tumor-immune and the tumor-host interactions are characterized to reproduce experimental results. A thorough dynamical analysis of the model is carried out, showing its capability to explain theoretical and empirical knowledge about tumor development. A chemotherapy treatment reproducing different experiments is also introduced. We believe ...[more]

PMID: 25348062

Publication: 1/2

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