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Lipniacki2004 - Mathematical model of NFKB regulatory module

ABSTRACT: its a mathematical model studying impact of TNF on NFKB nuclear dynamics. This model is derived from Hoffmann2002 (PMID:12424381).

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: BIOMD0000000786 | BioModels | 2019-08-09

REPOSITORIES: BioModels

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Mathematical model of NF-kappaB regulatory module.

Lipniacki Tomasz T Paszek Pawel P Brasier A R Allan R AR Luxon Bruce B Kimmel Marek M

Journal of theoretical biology 20040501 2

The two-feedback-loop regulatory module of nuclear factor kappaB (NF-kappaB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkappaB (IKK) and NF-kappaB, the inhibitors A20 and IkappaBalpha, and their complexes. In resting cells, the unphosphorylated IkappaBalpha binds to NF-kappaB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis f ...[more]

PMID: 15094015

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