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Schropp2019 - Target-Mediated Drug Disposition Model for Bispecific Antibodies

ABSTRACT: This model presents a general target-mediated drug disposition (TMDD) model for bispecific antibodies (BsAbs), which bind to two different targets on different cell membranes. The model includes four different binding events for BsAbs, turnover of the targets, and internalization of the complexes. In addition, a quasi-equilibrium (QE) approximation with decreased number of binding parameters is also present.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000788 | BioModels | 2019-08-12

REPOSITORIES: BioModels

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Target-Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation, and Optimal Dosing Strategy.

Schropp Johannes J Khot Antari A Shah Dhaval K DK Koch Gilbert G

CPT: pharmacometrics & systems pharmacology 20190108 3

Bispecific antibodies (BsAbs) bind to two different targets, and create two binary and one ternary complex (TC). These molecules have shown promise as immuno-oncology drugs, and the TC is considered the pharmacologically active species that drives their pharmacodynamic effect. Here, we have presented a general target-mediated drug disposition (TMDD) model for these BsAbs, which bind to two different targets on different cell membranes. The model includes four different binding events for BsAbs, ...[more]

PMID: 30480383

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