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Alvarez2019 - A nonlinear mathematical model of cell-mediated immune response for tumor phenotypic heterogeneity


ABSTRACT: This is a non-linear mathematical model of cancer immunosurveillance that takes into account intratumoral phenotypic heterogeneity, such as differential expression of cell surface receptors and growth factors, according to cell-mediated immune responses. The model describes phenomena that have also been observed in vivo, such as tumor dormancy, cancer immunoediting, and a strong sensitivity to initial conditions.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000790 | BioModels | 2019-08-12

REPOSITORIES: BioModels

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A nonlinear mathematical model of cell-mediated immune response for tumor phenotypic heterogeneity.

Alvarez Robinson F RF   Barbuto José A M JAM   Venegeroles Roberto R  

Journal of theoretical biology 20190329


Human cancers display intra-tumor heterogeneity in many phenotypic features, such as expression of cell surface receptors, growth, and angiogenic, proliferative, and immunogenic factors, which represent obstacles to a successful immune response. In this paper, we propose a nonlinear mathematical model of cancer immunosurveillance that takes into account some of these features based on cell-mediated immune responses. The model describes phenomena that are seen in vivo, such as tumor dormancy, rob  ...[more]

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